Organoids are simple cell-based in vitro tissue engineering models that can reproduce many aspects of the complex structure and function of their corresponding in vivo tissues. They can be dissected and analyzed to study the fundamental mechanisms of human tissue development, regeneration, and repair. They can also be used for diagnostics, disease modelling, drug development, and personalized medicine. Organoids can be derived from pluripotent stem cells, tissue-resident stem cells (embryonic or adult), progenitor cells or differentiated cells from healthy or diseased tissues (such as tumors). A large number of organoid engineering strategies supporting the culture, growth, proliferation, differentiation and maturation of organoids have been reported to date.